Tom Decorte, professor of criminology and director of the Institute for Social Drug research (ISD) at Ghent University, is in favour of cannabis regulation. What is his position on other substances like methamphetamine, heroin, cocaine, ecstasy, etc.? He sheds light on various aspects of the fine balance to be found between the advantages of regulation and the objective risks, the toxicity of these substances. Legalisation is not a magic bullet, but the real question is: do we want a policy that makes the problems, harms and risks associated with drug use even worse?